Laboratory of Cell Death Research and Therapy
We are studying cell death and resistance pathways in tumors, how they impact the interface between cancer cells and stromal cells, modify the tumor microenvironment and anticancer therapy responses. Our ultimate goal is to contribute to combating cancer by translating molecular/cellular knowledge into therapeutic possibilities.
Growing evidence highlight that efficient tumor clearance requires effective therapy-mediated debulking along with the engagement of the immune system. The induction of regulated cancer cell death (RCD) able to reinstate, rather than suppressing, anticancer immune responses is therefore a highly desirable therapeutic effect. To be immunogenic, namely to be able to activate the immune system, therapy-induced RCD needs to deliver tumor antigens along with a spectrum of danger signals with the ability - when properly decoded by the immune system- to sustain anti-tumor immunity. However, the recognition and clearance of residual cancer cells by the immune system, requires the inactivation of various immunoresistance mechanisms, including those preventing infiltration of cytotoxic T lymphocytes in the tumor. Autophagy is commonly heightened in cancer cells and supports tumor growth and resistance to therapy, but the role of autophagy in stromal cells is still largely underappreciated. In particular, whether and how endothelial cell (EC)-intrinsic autophagy modulates the EC-T cells interface and anti-tumor immunity is largely unknown.
To showcase the world-class scientific research of the Patrizia Agostinis Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
The Patrizia Agostinis Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.