Laboratory for Mechanisms of Cell Transformation
The focus of Anna Sablina’s group is to elucidate the role of ubiquitin system in human disease. To achieve this, she has been taking a multi-faceted approach; combining mouse modelling techniques with comprehensive biochemical and genetics studies.
Cell life depends on the interplay between vast networks of signalling pathways composed of about ten milliards of proteins per cell. Normal cell functioning requires that all these proteins act in a precise spatial and temporal manner. The ubiquitin system is a key to this process and perturbation of its function leads to the development and progression of a broad range of human diseases. Ubiquitination is a versatile and dynamic post-translational modification in which single ubiquitin molecules or polyubiquitin chains are attached to target proteins. Whereas the majority of research in the ubiquitin field was focused on degradative polyubiquitination, recent studies highlight the importance of single ubiquitin modification in normal cell operation.
To showcase the world-class scientific research of the Anna Sablina Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested to work on single-cell regulatory genomics - computational or experimental, please contact us.
The Anna Sablina Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.