Laboratory of Tumor Microenvironment and Therapeutic Resistance

The long-term goal of our lab is to conduct a comprehensive investigation that defines the dialogues of heterogeneous tumor cell subtypes, and the vasculature and immune cells in the distinct tumor vascular niches in response during progression as well as targeted therapies including antiangiogenic and immune-modulating therapies. 

Gabriele Bergers

Group Leader
VIB Group Leader, August 2016-present
Professor in the Department of Oncology, KU Leuven, Belgium
Adjunct Professor, University of California, San Francisco, USA, 2016-present
Full Professor,: University of California, San Francisco, USA, 2010-2016
Assistant/Associate Professor: Univ. of California, San Francisco, USA, 2001-2005/2005-2010
Research Scientist: Univ. of California, San Francisco, USA, 1994-2001

Research areas

Human diseases Cancer Biology

Model organisms

Research focus

The long-term goal of our lab is to conduct a comprehensive investigation that defines the dialogues of heterogeneous tumor cell subtypes, and the vasculature and immune cells in the distinct tumor vascular niches in response during progression as well as targeted therapies including antiangiogenic and immune-modulating therapies. The results forthcoming, will enable us to identify suitable polytherapies that are adapted to the heterogeneous cancer responses to more successfully impede therapeutic resistance and prolong survival.

Cancers are heterogeneous entities in which tumor cell populations as well as distinct host cell constituents form a dynamic and interactive tumor community that is pivotal not only for the genesis and progression of a tumor but also for the tumor’s ability to resist therapeutic elimination. Extensive characterization of the genome, epigenome and transcriptome of tumor cells has provided a higher-resolution picture of their alterations revealing substantial inter- and intra-tumor heterogeneity. 

Intratumoral High-Endothelial Venules (HEVs)

Publications 

To showcase the world-class scientific research of the Gabriele Bergers Lab, you can discover their scientific papers in more detail.

Jobs

We are always on the lookout for highly motivated colleagues to join our team. 

Team 

The Gabriele Bergers Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority. 

Events

To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.