Laboratory of Angiogenesis and Vascular Metabolism
Peter Carmeliet’s laboratory focuses on one central topic ”Angiogenesis”, the growth of new blood vessels, in health and disease. Abnormal blood vessel growth, excessive or insufficient, and dysfunction of blood vessels, contributes to multiple disorders, including cancer, cardiovascular disease, diabetes, age-related blindness, stroke, etc. Our ambition is to develop therapeutic concepts and, if possible, innovative anti-angiogenic treatments, in close collaboration with various clinicians of UZ Leuven.
Latest findings indicate that the efficacy of current anti-angiogenic therapy (targeting VEGF) in cancer is limited by intrinsic refractoriness and acquired drug resistance. There is thus an urgent medical need to improve clinical anti-angiogenic therapy. To remedy this problem, Peter Carmeliet’s team uses a fundamentally distinct approach and pioneered the study of endothelial cell (EC) metabolism during angiogenesis, hypothesizing that targeting the metabolic “engine” of ECs would paralyze blood vessel growth and normalize tumor vessels. The role of several key metabolic targets in endothelial cell biology and tumor angiogenesis are currently studied, also at the single cell level.
To showcase the world-class scientific research of the Peter Carmeliet Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested to work, please contact us.
The Peter Carmeliet Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.
Awards / Recognitions
Honorary Award Lecture Basic Science, German Cardiac Society
Münster Heart Center Award, Germany
Bristow Distinguished Lecture, Chicago, USA