Laboratory for Molecular Biology of Leukemia
We aim to understand the genetic complexity of leukemia and to use that information to develop novel treatment strategies.
We focus on acute lymphoblastic leukemia (ALL), the most common childhood cancer, and in particular on the subset of ALL that is affecting the T-cells. T-cell ALL is caused by the accumulation of 10 to 20 genomic lesions (chromosomal rearrangements and mutations) in immature lymphoid cells that leads to a high proliferation and impaired differentiation of developing T-cells. These lesions affect various transcription factors (TLX1, TLX3, HOXA, TAL1, NKX2.1) signaling pathways (CDKN2A, NOTCH1, JAK/STAT, AKT, RAS), as well as epigenetic regulators and ribosomal proteins.
To showcase the world-class scientific research of the Jan Cools Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested to work with us, let us know.
The Jan Cools Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.