Many important biological processes are regulated by large protein complexes. These complexes are typically dynamic: they often change their structure and even composition as they fulfill their biological role.

Rouslan Efremov

Group Leader
VIB group leader at VIB since April 2013
Postdoc: Max Planck Institute for Molecular Physiology, Dortmund, Germany, 2011-2012
Postdoc: MRC Mitochondrial Biology Unit, Cambridge, UK, 2006-2010
PhD: Moscow Institute for Physics and Technology, Moscow, Russia, 2005

Research areas

Structural biology Systems biology Computational biology Medical biotechnology

Research Focus

Our current focus is on a membrane protein ryanodine receptor, the largest known ion channel.  Ryanodine receptors play important role in many tissues in particular in contraction of skeletal and cardiac muscles. These ion channels are of significant medical importance as they represent important drug targets against cardiac and muscular diseases. We aim at determining the high-resolution structures of ryanodine receptors in multiple functional states. This will allow us to understand how numerous factors alter the protein conformation and regulate the ion transport.

In addition to studying the structure of the protein complexes we are interested in development of the method of single particle cryo-EM. Single particle cryo-EM has an immense not realized potential for determining high-resolution structures of challenging macromolecular complexes from a very small amount of material. Here our goal is to improve existing sample preparation and image processing approaches.

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We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.


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