Research at the Cytokine Receptor Lab (CRL) is centered around four main themes:
(1) mechanisms underlying receptor activation and the Jak/Stat pathway with the leptin receptor as a model system,
(2) analysis of protein-protein interactions, from analytical programs to large-scale interactomics using our in-house developed MAPPIT platform,
(3) the development of AcTakines, “Activity-on-Target” cytokines that display greatly reduced systemic toxicity, and
(4) understand signaling downstream of Toll-like receptors by extensive semi-automated mutagenesis analysis and molecular modeling
in combination with in-cellulo interaction assays.