Translational: Basic scientific research with a focus on novel anti-inflammatory therapies (to circumvent side effects), novel anti-cancer treatments (to overcome resistance and side effects) and the development of advanced GR-tailored drug screening platforms.

Nuclear Receptor: Focus on GR, MR, PPAR and ERR as individual drug targets and crosstalk mechanisms. These NRs (signaling and transcriptional mechanisms) are studied in-depth on a biomolecular level.

Research: Combining dry and wet lab experiments to validate fundamental insights in biologically/clinically relevant settings. Expertise with cell-based anti-inflammatory drug screening platforms.

Karolien De Bosscher

Expert Scientist
VIB Group Leader since January 2019
Postdoctoral Fellow/junior group leader: FWO-Vlaanderen, UGent (Belgium), 2002-2013
Postdoctoral Fellow: Cancer Research UK, London (UK), 2000-2002
PhD: UGent, Department Molecular and Biomedical Research, Faculty of Sciences, 2000

Research areas

Cancer Biology Medical biotechnology Structural biology

Research Focus

Currently, corticosteroids in the clinic are too often used with a “one-size-fits-all” rationale for the treatment/management of inflammatory diseases, metabolic disorders and cancer. Glucocorticoid receptor (GR) regulation and responses are far more complex than previously recognized. GR is not a “one-size-fits-all” type of target, but requires a tailored approach when it comes to drug discovery to meet the correct insight that GR is a receptor demonstrating a high degree of plasticity. Multiple GR conformations must exist, likely resulting in different anti-inflammatory (AI) profiles. Trying to achieve a selective GR-mediated activation of particular AI profiles may offer the potential for the development of safer and disease-tailored GR-targeting medicines.

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