The Kristel Sleegers lab is committed to increase insight in the complex genetics of Alzheimer’s disease and to investigate the translational potential of genetic discovery, by using state-of-the-art genetic-epidemiological methods and advanced genomic technologies to identify molecular mechanisms that can serve as future targets for early detection, prevention and treatment.
Alzheimer’s disease (AD) is a major societal challenge and a threat to health care systems. The field of AD genetics has developed tremendously over the past 10 years, but so far this progress has had very little translation into clinical diagnosis and prediction of progression of AD. The Kristel Sleegers lab aims to increase insight in the complex genetics of Alzheimer’s disease at a tissue- and cell type-specific level, and to investigate the translational potential of AD genetics in stratification, early detection and prediction of progression.
The lab is internationally recognized for its track record of identification of ‘culprit’ variants driving association signals, using (beyond) state-of-the-art genomic technologies on a well-characterized, biomaterial-rich, locally ascertained study population with close connections to clinicians. Identification of culprit variants and the context in which they exert their effect will make Alzheimer research and development as well as genetic risk profiling more efficient. Development of genetic profiling for adoption in early detection and stratification settings may have important impact, on individual health, on society and the health care system.
To showcase the world-class scientific research of the Kristel Sleegers Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
The Kristel Sleegers Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.