Laboratory of Translational Genetics

The Laboratory of Translational Genetics headed by Diether Lambrechts is a technology-driven translational research group. We aspire to tackle important questions in oncology by translating genome-scale data sets into clinically applicable knowledge. 

Diether Lambrechts

Science Director
Full Professor, Dept. of Human Genetics, Univ. of Leuven, Belgium since 2019
Science Director of the Sino-Belgian Lab for Single-Cell Analysis Technologies since 2019
VIB Science Director since 2017 (VIB Acting Director, 2015-2016)
Associate Professor, Dept. of Oncology, Univ. of Leuven, Belgium, 2012-2015
Assistant Professor, Dept. of Oncology, Univ. of Leuven, Belgium, 2009-2012
VIB Group leader since January 2008

Research areas

Human diseases Cancer Biology Cell Biology

Model organisms

Research focus

Our work is currently focused on two main research topics in the field of cancer genomics.

  1. Characterization how the tumor microenvironment (TME) determines tumor behavior and response to response to anti-angiogenic and checkpoint immunotherapies, which are both frequently used in the clinic (alone or in combination). This exciting line of research bears a lot of translational potential, as managing the levels of hypoxia in solid tumors by anti-angiogenic strategies represents a major yet incompletely understood challenge, while the field of immunotherapy is rapidly expanding - yet desperately in need of biomarkers predicting clinical response. We are using the newest single-cell profiling technologies to study these tumor micro-environments at the greatest detail (before, during treatment and at resistance).
  2. The use of plasma cell-free DNA (cfDNA) as a diagnostic test to characterize and monitor tumors non-invasively. Specifically, we are optimizing methods to reliably detect somatic mutations, copy number changes, but also changes in DNA methylation and nucleosome positions in cfDNA from cancer patients


To showcase the world-class scientific research of the Diether Lambrechts Lab, you can discover their scientific papers in more detail.


We are always on the lookout for highly motivated colleagues to join our team. If you are interested to work on single-cell regulatory genomics - computational or experimental, please contact us.


The Diether Lambrechts Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority. 


To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.