Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. Our primary focus is to examine the underlying molecular mechanisms that drive Alzheimer’s disease (AD) and Frontotemporal degeneration (FTD), with special focus on inflammatory networks and particularly the contribution of microglia. We use mouse models, iPSC and cutting-edge humanised mouse systems to determine the immune component of these disorders and determine how genetics alter microglial function and contribute to the initiation and perpetuation of brain disease.
Representative confocal images showing widespread distribution of human microglia (stained both in red and green) across multiple brain regions 4 weeks after transplantation. The left panel displays a sagittal section of the mouse brain (2mm lateral from midline), whereas and the right panels show higher magnification images of cortex and hippocampus.