Laboratory for Molecular Cancer Biology
Our research group focuses on the analysis of pathways that underlie the genesis, progression and maintenance of cancer. The goal is to understand how the genes that are implicated in cancer control fundamental cellular processes in normal cells. At the same time, we wish to understand the mechanisms by which non-mutational (i.e. epigenetic and post-transcriptional) events interfere with these natural processes to bring about tumour development and to affect therapy outcome.
Using melanoma as a disease paradigm, our laboratory focuses on the mechanisms by which cancer-specific non-mutational (i.e. epigenetic and (post-)transcriptional) events modulate tumor initiation, progression and therapy outcome. Using various in vitro and in vivo (i.e. Genetically engineered and patient-derived) models, we study several fundamental aspects of melanoma biology, including the nature and behaviour of melanoma initiating cells and the mechanisms that contribute to early tumor development and metastatic spreading, emergence of inter- and intra-tumor heterogeneity and resistance to both targeted- and immuno-therapy.
To showcase the world-class scientific research of the Jean-Christophe Marine Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
The Jean-Christophe Marine Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.