Laboratory for Molecular Cancer Biology

Our research group focuses on the analysis of pathways that underlie the genesis, progression and maintenance of cancer. The goal is to understand how the genes that are implicated in cancer control fundamental cellular processes in normal cells. At the same time, we wish to understand the mechanisms by which non-mutational (i.e. epigenetic and post-transcriptional) events interfere with these natural processes to bring about tumour development and to affect therapy outcome.

Jean-Christophe Marine

Science Director
VIB Science Director since 2017
VIB Group leader since 2004
Chercheur Qualifié FNRS, Brussels, Belgium, 2002-2004
Postdoc: European Inst. of Oncology (IEO), Milan, Italy, 2000-2002
Postdoc: St Jude Children's Research Hosp., Memphis, USA, 1996-1999
PhD: Univ. of Liège, Liège, Belgium, 1996

Research areas

Human diseases Systems biology Cancer Biology Cell Biology

Model organisms

Research focus

Using melanoma as a disease paradigm, our laboratory focuses on the mechanisms by which cancer-specific non-mutational (i.e. epigenetic and (post-)transcriptional) events modulate tumor initiation, progression and therapy outcome. Using various in vitro and in vivo (i.e. Genetically engineered and patient-derived) models, we study several fundamental aspects of melanoma biology, including the nature and behaviour of melanoma initiating cells and the mechanisms that contribute to early tumor development and metastatic spreading, emergence of inter- and intra-tumor heterogeneity and resistance to both targeted- and immuno-therapy.


MORE INFO

 

 

Publications

To showcase the world-class scientific research of the Jean-Christophe Marine Lab, you can discover their scientific papers in more detail.

Jobs

We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.

Team

The Jean-Christophe Marine Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.

Events

To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.