Mouse Genetics in Inflammation
The main goal of our research is to contribute to the understanding of the molecular mechanisms that are involved in the progression of sepsis.
Research areas
Immunology & inflammation Cancer Biology Human diseases Computational biology MicrobiologyModel organisms
Research topics
Research Focus
The main goal of our research is to contribute to the understanding of the molecular mechanisms that are involved in the progression of sepsis.
Sepsis is a most deadly disease that is initiated by a (bacterial) infection and leads to a severe host response. It hits 49 million people yearly, 11 million of which die (a big fraction being children). The savage, acute and complex nature of sepsis has caused much confusion as to the most relevant molecular mechanisms involved. Since many clinical trials for sepsis have failed, the classical belief that sepsis is primarily inflammatory in nature is under pressure. In our group, we focus our attention on metabolic reprogramming in sepsis, which we think follows a pattern that is compatible with an extremely acute starvation response, but which fails due to the inhibition of the function of several important transcription factors, such as the Glucocorticoid Receptor and PPARa and HNF4a. The molecular pathways that undermine these factors form a central theme in our research.
Publications
To showcase the world-class scientific research of the Claude Libert Lab, you can discover their scientific papers in more detail.
Jobs
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
Team
The Claude Libert Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
Events
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.
