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geen vertaling beschikbaar Molecular machines and evolutionary riddles: The savvides group Elucidates both

09/07/2019

A research team from Savvas Savvides’ lab in the VIB-UGent Center for Inflammation Research, led by Kenneth Verstraete, has unraveled the three-dimensional structure and molecular mechanism of ATP citrate lyase (ACLY). This is a central metabolic enzyme needed to produce acetyl-CoA which fuels essential biochemical processes in cells, such as the production of fatty acids and cholesterol. Their findings could help with targeting ACLY in cancer and metabolic diseases such as atherosclerosis.

geen vertaling beschikbaar Structure of the molecular machine that links carbohydrate and lipid metabolism

03/04/2019

A research team led by dr. Kenneth Verstraete in the Unit for Structural Biology at the VIB-UGent Center for Inflammation Research has unraveled the three-dimensional structure and molecular mechanism of ATP citrate lyase (ACLY). This is a central metabolic enzyme – a protein that accelerates chemical reactions – important for the production of fatty acids and cholesterol in the human liver. The reported findings could help targeting ACLY in cancer and metabolic diseases such as atherosclerosis. 

geen vertaling beschikbaar Belgian researchers discover a novel method to block immunosuppression in cancer

25/10/2018

Belgian research groups from the UCLouvain and WELBIO, VIB and Ghent University, and the biotechnology company argenx elucidated the three-dimensional structure of an assembly of proteins operating on cells that dampen immune responses. They also discovered how an antibody can block this assembly and the immunosuppression it induces downstream. Such an antibody could serve to stimulate immunity against tumor cells in cancer patients, triggering the destruction of their tumors by immune cells. The study is published in the authoritative journal Science.
 

geen vertaling beschikbaar Scientists shed light on a key molecular mechanism of autoimmune and inflammatory diseases

17/01/2018

An international team of researchers led by prof. Savvas Savvides (VIB-UGent Center for Inflammation Research) has unraveled a crucial aspect of the molecular basis of autoimmune and inflammatory diseases such as psoriasis, rheumatoid arthritis and Crohn’s disease. Focusing on the immunomodulatory cytokine IL-23 they discovered that its pro-inflammatory activity, which underlies a wide range of inflammatory diseases, critically depends on structural activation of the cytokine by its receptor, IL-23R. The results of the study are published in the leading journal Immunity.

geen vertaling beschikbaar Protein responsible for allergic diseases exposed

14/07/2017

Scientists at the VIB-UGent Center for Inflammation Research have managed to unravel the functioning of what is thought to be the ‘master protein’ that drives a range of widespread allergic diseases, such as asthma and eczema. On a molecular level, the team described how a protein called TSLP assembles with its molecular partners at the surface of cells. This is the cornerstone of TSLP’s bioactivity. These insights, published in the leading scientific journal Nature Communications, also enabled the team to develop a new molecule that can block TSLP’s activity. Due to the molecule’s promise in terms of the development of new therapies for widespread allergic conditions, the researchers are currently planning follow-up studies and seeking industrial partnerships.

geen vertaling beschikbaar Scientists expose protein responsible for allergic diseases

04/04/2017

Scientists at VIB-UGent have managed to unravel the functioning of what is thought to be the ‘master protein’ that drives a range of widespread allergic diseases, such as asthma and eczema. On a molecular level, the team described how a protein called TSLP assembles with its molecular partners at the surface of cells. This is the cornerstone of TSLP’s bioactivity. These insights, published in the leading scientific journal Nature Communications, also enabled the team to develop a new molecule that can block TSLP’s activity. Due to the molecule’s promise in terms of the development of new therapies for widespread allergic conditions, the researchers are currently planning follow-up studies and seeking industrial partnerships.

geen vertaling beschikbaar Researchers unravel viruses’ strategies to dodge immune systems

07/11/2016

​As mammals evolve, so do mammalian viruses. In doing so, they develop creative and effective ways to counter and evade the antiviral responses of their mammal hosts’ immune systems. Researching those mechanisms at the molecular level can reveal key insights into the principles of such strategies relevant to therapy development. An international team of scientists, led by prof. Savvas Savvides of the VIB Inflammation Research Center at Ghent University, set out to do just that. By zooming in on GIF — a protein secreted by the virus that causes Orf, or ‘thistle disease’ — they unraveled viral molecular strategies to counter the mammalian immune system. Their findings, published in Nature Communications, provide the basis for developing antiviral therapies and for exploiting the potency of viral proteins to tweak the human immune system to counter inflammatory diseases and cancer.