Work in our group focuses on the structural molecular biology of bacterial cell surfaces & host-pathogen interactions.

Han Remaut

Deputy Science Director
VIB Science Director since 2017
VIB Group leader since 2009
Postdoc.: Inst. for Structural Molecular Biology, School of Crystallography, Birkbeck College, UK, 2003-2008
PhD: Ghent University, Ghent, Belgium, 2003
Phone: 0499708050

Research areas

Structural biology Microbiology Medical biotechnology

Research Focus

For most pathogenic bacteria, a crucial initial step in the establishment of infection is the recognition and colonization of the host tissue by specific attachment via surface-exposed adhesion molecules. In gram-negative bacteria, these adhesins are displayed on the outer membrane as single proteins (e.g. autotransporters or two-partner secretion systems) or can be incorporated into filamentous polymers (chaperone/usher pili, type II pili, type IV secretion pili and curli). Adhesin-mediated attachment can simply serve as a means of avoiding clearance through mechanical shear, or can trigger more complex host responses like cytoskeleton reorganization and cell invasion, or provide the required proximity to the host cell to enable other virulence mechanisms to come into action (e.g. effector injection through type III and type IV secretion systems). In an era of increased antibiotics resistance and difficulties in controlling hospital-acquired infections, it is essential to gain a better understanding of the fundamental principles governing the infection process. Our lab studies the structural molecular biology of bacterial adhesins and cell-surface filaments with respect to their function in bacterial pathogenesis, with the ultimate aim of developing a new generation of virulence-targeted antimicrobials.

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Publications

To showcase the world-class scientific research of the Han Remaut Lab, you can discover their scientific papers in more detail.

Jobs

We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.

Team

The Han Remaut Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.

Events

To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.

Funding