Mononuclear Phagocytes in Health and Disease
Our lab is focused on unravelling heterogeneity and function within myeloid cells particularly in the context of tissue damage and Inflammation in mice and humans. Specifically, we are Interested in myeloid cells in the liver and intestine and the potential links between these two organs.
Research areas
Human diseases Molecular neurology Immunology & inflammation Computational biologyModel organisms
Research topics
Research Focus
Our lab is focused on unravelling heterogeneity and function within myeloid cells particularly in the context of tissue damage and Inflammation in mice and humans. Specifically, we are Interested in myeloid cells in the liver and intestine and the potential links between these two organs. To do this, we use state of the art techniques including single cell RNA sequencing, CITE-seq and 28-parameter flow cytometry alongside specific in vivo mouse models including the Clec4F-Cre to target Kupffer cells in the liver, the Xcr1-Cre to target cDC1s and the Fcgr1-Cre to target all macrophages.
Presence of lipid (purple) in lean versus obese liver. We are studying how the macrophages present (yellow) deal with this lipid and how these cells could be manipulated to help.
Publications
To showcase the world-class scientific research of the Charlotte Scott Lab, you can discover their scientific papers in more detail.
Jobs
We are always on the lookout for highly motivated colleagues to join our team. If you are interested to work on understanding myeloid cell biology in the setting of inflammation in the intestine or liver, please contact us.
Team
The Charlotte Scott Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
Events
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.
