Laboratory Of Molecular Cell Biology
We are interested in the development of research lines in which fundamental research leads to practical biotechnological applications. We have two main research lines: nutrient sensing and signal transduction in Candida albicans, and trehalose metabolism and stress tolerance in plants.
Technique development in candida
Despite recent advances in the field, experimentation involving Candida species is hampered by some major challenges.
An example in this respect is the aberrant codon usage of Candida albicans, the most prevalent Candida species. As a consequence, any genetic material has to be custom-made for this pathogen and no direct transfer of techniques from other organisms can be made. In this subsection of our laboratory, we focus on optimization of tools spaecifically for use in Candida albicans and Candida glabrata. We recently published optimized Candida two-hybrid and BiFC (bimolecular fluorescence complementation) tools for determination of protein-protein interactions in C. albicans. We also generated FRET (fluorescence resonance energy transfer)-based sensors for determination of secondary messenger, cAMP, levels and protein kinase A (PKA) activity in C. glabrata. Ongoing research is performed to develop more microscopy tools for improved (e.g. super-resolution) visualization of cellular processes in both fungi.
Caption picture: Variability in Candida albicans
To showcase the world-class scientific research of the Patrick Van Dijck Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
The Patrick Van Dijck Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority. Meet the team members who contributed to our breakthrough science.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.