The Rosa Rademakers Lab is focused on the discovery and functional characterization of novel disease genes implicated in a range of neurological disorders, in particular frontotemporal lobar degeneration (FTLD) and related disorders and epilepsy.
FTLD represents 10-20% of all dementias and is clinically important because of its early onset and its dramatic impact on core human qualities, including personality, insight and verbal communication. While significant progress has been made in recent years to improve our understanding of the genetics of FTLD and the pathologies underlying this collection of neurodegenerative diseases, the etiology of the disease remains unknown in more than half of the patients.
Rare variant association analysis
Amyotrophic lateral sclerosis (ALS)
Frontotemporal dementia (FTD)
The Rademakers Lab leads world-wide consortia to identify causal genes and genetic risk factors for two important pathological subtypes of FTLD: FTLD with TDP-43 pathology (FTLD-TDP) and FTLD with FUS pathology (FTLD-FUS). We combine genomic, transcriptomic, epigenomic and proteomic analyses, including single-cell analyses on unique collections of FTLD-TDP and FTLD-FUS brain tissues to identify genes and pathways implicated in disease. We also lead consortia focused on genetic disease modifiers in FTLD patients which are known to carry mutations in GRN and C9orf72 with the goal to identify factors that could explain the large variability in symptom onset, clinical phenotype and disease penetrance in patients with these mutations.
To showcase the world-class scientific research of the Rosa Rademakers Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
The Rosa Rademakers Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.
- Highly Cited Researcher, in recognition of ranking among the top 1% researchers most cited in Neuroscience & Behaviorin in 2014, 2015, 2016, 2017, 2018 & 2019 - Thomson Reuters
- Mildred A. and Henry Uihlein II Professorship of Medical Research in 2015 - Mayo Clinic, College of Medicine (Endowed Professorship)
- Mayo Clinic Investigator of the Year in 2012 - Neuroscience, Mayo Clinic, Jacksonville, Florida
- Jacksonville Business Journal Health Care Hero Award on 2011- Jacksonville Business Journal, Jacksonville, Florida