Many important biological processes are regulated by large protein complexes. These complexes are typically dynamic: they often change their structure and even composition as they fulfill their biological role.
Our current focus is on a membrane protein ryanodine receptor, the largest known ion channel. Ryanodine receptors play important role in many tissues in particular in contraction of skeletal and cardiac muscles. These ion channels are of significant medical importance as they represent important drug targets against cardiac and muscular diseases. We aim at determining the high-resolution structures of ryanodine receptors in multiple functional states. This will allow us to understand how numerous factors alter the protein conformation and regulate the ion transport.
In addition to studying the structure of the protein complexes we are interested in development of the method of single particle cryo-EM. Single particle cryo-EM has an immense not realized potential for determining high-resolution structures of challenging macromolecular complexes from a very small amount of material. Here our goal is to improve existing sample preparation and image processing approaches.
To showcase the world-class scientific research of the Rouslan Efremov Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
The Rouslan Efremov Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.