Each year, Clarivate publishes a ‘highly cited researchers’ list recognizing pioneers in their field. This list contains researchers who have demonstrated significant influence through the publication of multiple papers, highly cited by their peers, during the last decade (2009-2019). No less than 19 VIB researchers are part of this highly acclaimed group of influential scientists.
A unique collaborative effort by the De Rybel (VIB-UGent Center for Plant Systems Biology) and Saeys (VIB-UGent Center for Inflammation Research) labs has pioneered the development of single-cell transcriptomics in plants. In doing so, they identified how plants translate indications of low phosphate availability into growth adaptation.
The Chan Zuckerberg Initiative announced $3.8 million in funding for 23 grants to support open-source software projects essential to biomedical research. Software by the lab of Yvan Saeys (VIB-UGent) for the analysis and visualization of single-cell data is one of the projects that will receive funding as part of CZI’s Essential Open Source Software for Science (EOSS) program.
For the first time, scientists from the VIB Center for Inflammation Research, Ghent University, The Wellcome Sanger Institute (UK), and Newcastle University (UK) have composed a complete map of the cells in the developing human thymus. This novel approach with single cell resolution allowed them to identify more than 50 different cell states in the human thymus which dynamically change in abundance during life.
Computational biologists led by Prof. Yvan Saeys (VIB-UGent Center for Inflammation Research) developed a new bioinformatics method to better study communication between cells. This method, called NicheNet, helps researchers to gain insight into how the gene expression of cells is regulated by interacting cells. NicheNet has a broad range of potential applications in fields like immunology and tumor biology.
This large-scale public-private research initiative will provide new insights into the response and non-response to treatment within seven different immune-mediated diseases. 3TR will use integrated, cross-disease analysis of the most state-of-the-art profiling technologies.
Our brains do not only contain neurons, but also a variety of immune cells that play an important role for its functioning. A team led by Dr. Kiavash Movahedi (VIB Center for Inflammation Research at VUB) has developed a comprehensive cell atlas of the brain's immune compartment. This revealed not only the striking diversity of brain macrophages, but also found microglia where they were not expected.
What happens inside a cell when it is activated, changing, or responding to variations in its environment? Researchers from the VIB-UGent Center for Inflammation Research have developed a map of how to best model these cellular dynamics. Their work not only highlights the outstanding challenges of tracking cells throughout their growth and lifetime, but also pioneers new ways of evaluating computational biology methods that aim to do this.
A common theme across all VIB core facilities is the generation of potentially huge datasets that require powerful analysis tools to make sense of the data being generated. As many core facilities explore state-of-the-art technologies, plenty of research is still needed to develop and benchmark data analysis tools that translate this data into new biological knowledge.
In science, business and society, the term big data has been on the rise for quite some time now. The last decade, however, the concept has evolved from an all-round label to tangible applications that affect our lives in numerous ways. In life sciences as well, big data technology is helping us cope with a seemingly endless tsunami of biological information. And considering the rapid pace of progress in our sector, we’re just seeing the tip of the iceberg.