We aim to improve the co-complex methods on different levels with the ultimate goal to provide a high resolution context-dependent association profile for the protein of interest. Virtually all available methods rely on lysis or homogenization as a first step in the protocol. With the Virotrap platform (developed on the interface of the Tavernier and Gevaert labs), we prevent the need for lysis by trapping the protein complex under native conditions in virus-like particles that bud from human cells. Classical proteomic approaches can then reveal the content of these particles. The unique data generated by Virotrap required new analysis tools resulting in ‘Sfinx’, a straightforward filtering strategy which outperforms available tools, also on AP-MS datasets.
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