Our research group develops innovative technologies to study protein-protein complexes. Moreover we persue the implementation of genome engineering approaches to push co-complex analysis at the endogenous protein level.  

Sven Eyckerman

Expert Scientist
VIB Expert Scientist since 2015
Postdoc: VIB, Jan Tavernier and Kris Gevaert Lab, Ghent, 2008-2014
Sr Scientist: Pronota NV, Ghent, Belgium, 2006-2009
Postdoc: Swiss Inst. for Experimental Cancer Res. (ISREC), Lausanne, Switzerland, 2004-2006
PhD: Ghent Univ., Ghent, Belgium, 2002

Research areas

Systems biology Medical biotechnology Computational biology

Research Focus

We aim to improve the co-complex methods on different levels with the ultimate goal to provide a high resolution context-dependent association profile for the protein of interest. Virtually all available methods rely on lysis or homogenization as a first step in the protocol. With the Virotrap platform (developed on the interface of the Tavernier and Gevaert labs), we prevent the need for lysis by trapping the protein complex under native conditions in virus-like particles that bud from human cells. Classical proteomic approaches can then reveal the content of these particles. The unique data generated by Virotrap required new analysis tools resulting in ‘Sfinx’, a straightforward filtering strategy which outperforms available tools, also on AP-MS datasets.

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Publications

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Jobs

We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.

Team

The Sven Eyckerman Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.

Events

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