Molecular Signaling and Cell Death

Cell death is a crucial process in development, homeostasis and (patho)physiology. In normal conditions about 100 billion cell die mostly by apoptosis. 

Research areas

Human diseases Immunology & inflammation

Model organisms

Research Focus

Cell death is a crucial process in development, homeostasis and (patho)physiology. In normal conditions about 100 billion cell die mostly by apoptosis. However, many diseased conditions are associated with a deregulated balance in cell death. Too much or too sensitive cell death is associated with inflammatory and degenerative diseases, while too little or too insensitive cell death is associated with development of cancer and with therapeutic resistance. This implies that depending on the particular role of cell death in a given disease therapeutic strategies could be envisioned that either sensitize or desensitize cell death pathway. However, in order to do so, a profound knowledge is required not only of cell death pathway but also on the molecular mechanism that regulate these cell death pathways.

 

Publications

To showcase the world-class scientific research of the Peter Vandenabeele Lab, you can discover their scientific papers in more detail.

Jobs

We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.

Team

The Peter Vandenabeele Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.

Events

To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.

Vandenabeele Lab news

Scientists shed new light on infection process of the gastrointestinal pathogen C. difficile

21/11/2018

Scientists from the VIB-UGent Center for Inflammation Research identified the mechanisms by which the bacterial pathogen Clostridium difficile kills intestinal epithelial cells (IECs), thus destroying the protective mucosal barrier of the intestinal tract. The researchers demonstrate the physiological relevance of this process during infection and have published their findings in Nature Communications.

New weapon against chemotherapy-resistant cancer cells discovered

16/07/2018

​Neuroblastoma, one of the most common aggressive forms of cancer in many young children, exhibits an increased resistance to the current generation of chemotherapy. To be able to treat these sorts of tumors, a new type of therapy is required. Research from VIB, Ghent University and the University of Antwerp, led by the brothers Tom and Wim Vanden Berghe, has led to the discovery of a new molecular mechanism that can kill cancer cells in mice. Withaferin A, an active substance from a medicinal plant extract (Ashwagandha) from traditional medicine in India, plays an important role in this. These insights were published in the prestigious scientific journal, ‘Journal of Clinical Investigation’.