Comparative Network Biology
The scientific objective of our research group is to extract biological knowledge from large-scale experimental data sets using data integration, comparative sequence and expression analysis, and network biology. Through the development and application of novel bioinformatics methods, new aspects of genome biology, especially in the area of gene function prediction and gene regulation, are identified. One of the main goals is to develop and apply comparative network biology methods to translate biological knowledge from model species to crop.
During the last couple of years, we have mapped gene regulatory networks in Arabidopsis using a variety of experimental and computational methods. Apart from developing a transcription factor (TF)-target gene identification workflow based on the integration of novel protein-binding microarray data and multi-species promoter sequence conservation, we have also mapped regulatory interactions using >30 ChIP-Seq data sets. We actively develop new comparative methods to identify conserved non-coding sequences in dicots and monocots and have demonstrated how these show high specificity to map functional TF-target genes in plants. Whereas initial network analysis focused on the model species Arabidopsis, we are in the process of expanding our network portfolio to other dicots (e.g. poplar, soybean) and are exploring new opportunities to perform network-based gene analysis in cereals as well (maize, wheat).
To showcase the world-class scientific research of the Klaas Vandepoele Lab, you can discover their scientific papers in more detail.’
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
The Klaas Vandepoele Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.