Human influenza is a contagious disease caused by influenza A or B viruses. Influenza is characterized by high morbidity and considerable mortality especially among the elderly and certain risk groups. Influenza A viruses circulate in several animal species and create problems, in terms of animal welfare, but also as a reservoir of new genes for humans influenza A viruses. Influenza is a vaccine-preventable disease and a few small molecule antiviral drugs are available.
One important aim of our research is to develop novel vaccines and antivirals against influenza. For this we focus on the influenza A virus M2 protein and on the viral neuraminidase. We are particularly interested in the protective mechanisms of action of such novel influenza vaccines. We study how interferon induced Mx1 counteracts influenza viruses. We are also pursuing a new approach to develop a cross-protective vaccine against influenza B virus and are developing novel antibody-based therapeutics against influenza viruses.
To showcase the world-class scientific research of the Xavier Saelens Lab, you can discover their scientific papers in more detail.
We are always on the lookout for highly motivated colleagues to join our team. If you are interested, please contact us.
The Xavier Saelens Lab can only thrive thanks to the dedication and commitment of its people, no matter what their function or seniority.
To stay up to date in rapidly developing fields, scientists regularly interact with (international) colleagues. Conferences and other (scientific) events are an excellent way to facilitate such a continent-spanning knowledge exchange.