Inhalable biologics to control respiratory infections
The main goal of this project is to come up with a radically different approach to control influenza. The general aim is to create biologicals that will be applied locally to treat and/or prevent influenza. The team will focus on the following specific goals:
Development of a pan-influenza A neutralizing biological that will be effective against all influenza A strains and can be used every season and during global outbreaks.
Generation of a stable cell line to produce the anti-influenza biologicals compliant with industrial production guidelines.
Creation of a formulation that allows nebulization and hence local delivery of the biological in the airways.
Execution of a cost-effectiveness study of the proposed biological-based solution with a focus on the prophylactic treatment in the elderly.