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Structural Biology

Structural biology uses new technologies, such as cryo-electron microscopy (cryo-EM) and novel approaches to imaging in cell biology to understand three-dimensional submicroscopic structures.

VIB scientists study the structure and dynamics of macromolecular (often protein) complexes in health and disease to explain their mode of action. They integrate structural biology work with genetic and cellular studies to bridge molecular and cellular resolution. The goal? To translate discoveries into biotechnological and medical applications.

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Nanobodies, our legacy

Nanobodies, our legacy

In 1989, Professor Raymond Hamers' laboratory at VUB discovered a new type of antibody in the blood of a dromedary. This led to the development of single-domain antibodies known as VHHs or Nanobodies® by former VIB researcher Serge Muyldermans. These tiny antibody fragments have resulted in the establishment of five VIB spin-off companies, including Ablynx, Biotalys, Confo Therapeutics, ExeVir Bio, and Animab. These companies are exploring the potential of VHHs as therapeutics for human and livestock diseases, crop protection, and drug discovery. Ongoing research at VIB continues to contribute to technological innovations in the VHH field.
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Center for Structural Biology

At CSB, we study the structure and dynamics of macromolecular complexes in health and disease to explain their mode of action. We integrate our structural biology work with genetic and cellular studies, aiming to bridge molecular and cellular resolution. We excel in translating our discoveries into biotechnological and medical applications.

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